Friday, September 28, 2012

NLRP3 promotes inflammation-induced skin cancer but is ...

NLRP3 promotes inflammation-induced skin cancer but is dispensable for asbestos-induced mesothelioma.

Immunol Cell Biol. 2012 Sep 25;

Authors: Chow MT, Tschopp J, M?ller A, Smyth MJ

Abstract
Asbestos exposure can result in serious and frequently lethal diseases, including malignant mesothelioma. The host sensor for asbestos-induced inflammation is the NLRP3 inflammasome and it is widely assumed that this complex is essential for asbestos-induced cancers. Here, we report that acute interleukin-1? production and recruitment of immune cells into peritoneal cavity were significantly decreased in the NLRP3-deficient mice after the administration of asbestos. However, NLRP3-deficient mice displayed a similar incidence of malignant mesothelioma and survival times as wild-type mice. Thus, early inflammatory reactions triggered by asbestos are NLRP3-dependent, but NLRP3 is not critical in the chronic development of asbestos-induced mesothelioma. Notably, in a two-stage carcinogenesis-induced papilloma model, NLRP3-deficient mice showed a resistance phenotype in two different strain backgrounds, suggesting a tumour-promoting role of NLRP3 in certain chemically-induced cancer types.Immunology and Cell Biology advance online publication, 25 September 2012; doi:10.1038/icb.2012.46.

PMID: 23010873 [PubMed - as supplied by publisher]

Tagged with: Immunol Cell Biol ? Mesothelioma

Filed under: Immunol Cell Biol

Like this post? Subscribe to my RSS feed and get loads more!

Source: http://www.mesothelioma.law.pro/nlrp3-promotes-inflammation-induced-skin-cancer-but-is-dispensable-for-asbestos-induced-mesothelioma/

greg smith catamount mike dantoni bulls heat goldman sachs brandon carr knicks coach

No comments:

Post a Comment

Note: Only a member of this blog may post a comment.