NLRP3 promotes inflammation-induced skin cancer but is dispensable for asbestos-induced mesothelioma.
Immunol Cell Biol. 2012 Sep 25;
Authors: Chow MT, Tschopp J, M?ller A, Smyth MJ
Abstract
Asbestos exposure can result in serious and frequently lethal diseases, including malignant mesothelioma. The host sensor for asbestos-induced inflammation is the NLRP3 inflammasome and it is widely assumed that this complex is essential for asbestos-induced cancers. Here, we report that acute interleukin-1? production and recruitment of immune cells into peritoneal cavity were significantly decreased in the NLRP3-deficient mice after the administration of asbestos. However, NLRP3-deficient mice displayed a similar incidence of malignant mesothelioma and survival times as wild-type mice. Thus, early inflammatory reactions triggered by asbestos are NLRP3-dependent, but NLRP3 is not critical in the chronic development of asbestos-induced mesothelioma. Notably, in a two-stage carcinogenesis-induced papilloma model, NLRP3-deficient mice showed a resistance phenotype in two different strain backgrounds, suggesting a tumour-promoting role of NLRP3 in certain chemically-induced cancer types.Immunology and Cell Biology advance online publication, 25 September 2012; doi:10.1038/icb.2012.46.
PMID: 23010873 [PubMed - as supplied by publisher]
Tagged with: Immunol Cell Biol ? Mesothelioma
Filed under: Immunol Cell Biol
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